Ketogenic Diet and Immunotherapy: A Promising Combination for Prostate Cancer

Researchers from the University of Notre Dame discovered that a ketogenic diet can alter the epigenetic and immune landscape of prostate cancer, making the cancer cells more susceptible to immune checkpoint blockade therapy. In laboratory settings, the addition of a pre-ketone supplement—a key component of the ketogenic diet—proved highly effective in reducing prostate cancer cells​.

The methodology involved in these studies included detailed genetic and epigenetic analyses, as well as monitoring changes in immune cell activity. The significant findings indicated that the ketogenic diet not only supports the immune system in targeting cancer cells but also helps in overcoming resistance to immunotherapy. This dual approach could lead to more robust and sustained cancer control​​.

Future clinical applications are being explored, with ongoing research aimed at translating these promising laboratory results into effective human treatments. The integration of dietary interventions like the ketogenic diet into standard cancer treatment protocols could offer new hope for patients with prostate cancer, especially those with treatment-resistant forms of the disease​.

For more detailed information, you can read the full studies on ScienceDaily and ScienceDaily.