Ketogenic Diet Found to Help with Early Stages of Alzheimer’s Disease

A groundbreaking study from the University of California, Davis, has revealed that the ketogenic diet significantly slows cognitive decline in the early stages of Alzheimer’s disease, particularly in mice. Researchers discovered that the diet, which is high in fat and low in carbohydrates, boosts the production of beta-hydroxybutyrate (BHB), a molecule that enhances the function of synapses and improves memory formation.

The study demonstrated that mice on a ketogenic diet for seven months exhibited remarkable improvements in synaptic function, which is critical for memory. The increased levels of BHB, almost sevenfold, were pivotal in preventing early memory decline. This effect is particularly notable because it supports the idea that BHB and the ketogenic diet may delay the progression of mild cognitive impairment and potentially Alzheimer’s disease itself.

Interestingly, the benefits of the ketogenic diet appeared more pronounced in female mice, who also had higher levels of BHB. This finding is particularly relevant for women, who are at a higher risk for Alzheimer’s due to genetic factors such as the ApoE4 gene variant.

The researchers are optimistic about translating these findings to human treatments. They suggest that BHB supplements could potentially support memory improvement in humans, although further studies are necessary to confirm this.

For more detailed information, you can read the full study on Medical Xpress and UC Davis Health.